β sitosterol no  (Larodan)

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Structure of (A) 24-methylene cycloartanyl ferulate (24-MCF), (B) γ-tocotrienol and (C) β-sitosterol. Chemical structures were drawn using ChemDraw Professional (64-bit; 22.2.0.3300).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques:

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Stability of RBO-NE B3 during storage for 3 months at 4 °C, including (A) Z av and PDI, (B) 24-MCF, γ-tocotrienol and β-sitosterol content (Mean ± SD, n = 6, p > 0.05, Kruskal Wallis test).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques:

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Total deposition in porcine skin of 24-MCF, γ-tocotrienol and β-sitosterol after application of RBO-NE and control formulation (10% RBO dispersed in a 1% HPMC solution) under infinite dose conditions for 8 h. The dashed line indicates endogenous β-sitosterol. (Mean ± SD, n = 6, ** p < 0.01, Mann-Whitney test).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques: Control, Formulation, MANN-WHITNEY

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Cutaneous biodistribution profiles in porcine skin: (A) 24-MCF and (B) γ-tocotrienol after application of the control formulation and RBO-NE B3 under infinite dose conditions for 8 h. The corresponding biodistribution profile of β-sitosterol are shown in (C) control formulation and (D) RBO-NE B3, with the endogenous β-sitosterol indicated by hatched lines (Mean ± SD, n = 6).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques: Control, Formulation

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Delivery of 24-MCF, γ-tocotrienol and β-sitosterol to PSU-containing and PSU-free porcine skin biopsies after application of (A) control formulation and (B) RBO-NE B3 under infinite dose conditions for 8 h. The dashed line: endogenous β-sitosterol. (Mean ± SD, n = 9, *** p < 0.0005, ** p < 0.005, * p < 0.05, ns = no significant difference, Mann-Whitney test).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques: Control, Formulation, MANN-WHITNEY

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Total deposition of 24-MCF, γ-tocotrienol, and β-sitosterol following a finite dose application of RBO-NE for different time applications on (A) porcine and (B) human skin. The data of β-Sitosterol was shown after subtraction with the endogenous level in both skin (Mean ± SD, n = 6).

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques:

Journal: International Journal of Pharmaceutics: X

Article Title: Cutaneous delivery of bioactive components from a rice bran oil nanoemulsion and their biodistribution in porcine and human skin

doi: 10.1016/j.ijpx.2026.100543

Figure Lengend Snippet: Cutaneous biodistribution profile of (A) 24-MCF, (B) γ-tocotrienol, and (C) β-sitosterol in porcine skin, (D) β-sitosterol in human skin following finite dose application of RBO-NE B3 for 8 h on porcine and human skin.

Article Snippet: 24-MCF was bought from ChemFaces (Wuhan, China). β-sitosterol was purchased from MedChem Express (Lucerne, Switzerland).

Techniques:

Journal: Molecules

Article Title: An Updated and Comprehensive Review of Phellodendri amurensis Cortex: Ethnobotany, Geographical Distribution, Phytochemistry, Quality Control, and Pharmacology

doi: 10.3390/molecules31081318

Figure Lengend Snippet: Steroids isolated or identified from Phellodendron amurense Rupr.

Article Snippet: 111. , β -Sitosterol , C 28 H 48 O , 400.3705 , Tieling, Liaoning Province, China , IR, 1 H NMR, 13 C-NMR, ESI-MS, HR-ESI-MS , [ ] .

Techniques: Isolation, Molecular Weight

Journal: Frontiers in Medicine

Article Title: Network pharmacology, machine learning, and experiments uncover β-sitosterol targeting HSP90AA1 in medicinal-edible black soybean against aging

doi: 10.3389/fmed.2026.1749856

Figure Lengend Snippet: β-sitosterol attenuates UVA-induced photoaging in HSFs. (A) Cell viability assay determining optimal β-sitosterol concentration. (B) Proliferation activity of HSFs under graded UVA irradiation. (C) β-sitosterol-mediated suppression of UVA-induced senescence. (D) Analysis of p16/p53 mRNA expression. (E) mRNA level of MMP-1 demonstrating β-sitosterol inhibition of UVA-induced matrix degradation. (F) Antioxidant profiles and MDA levels under UVA exposure with/without β-sitosterol pretreatment. Data shown as mean ± SEM, n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001.

Article Snippet: The cells were maintained at 37°C in an atmosphere containing 5% CO2. β-sitosterol (Tokyo Chemical Industry, Tokyo, Japan) was dissolved in the culture medium and used at a concentration of 25, 50 or 100 μg/mL for 24 h treatment.

Techniques: Viability Assay, Concentration Assay, Activity Assay, Irradiation, Expressing, Inhibition

Journal: Frontiers in Medicine

Article Title: Network pharmacology, machine learning, and experiments uncover β-sitosterol targeting HSP90AA1 in medicinal-edible black soybean against aging

doi: 10.3389/fmed.2026.1749856

Figure Lengend Snippet: HSP90AA1 mediates β-sitosterol’s anti-photoaging effects. (A) HSP90AA1 expression upregulated by UVA and further enhanced by β-sitosterol (mRNA). (B,C) Co-treatment with HSP90AA1 inhibitor IPI-504 reverses β-sitosterol-induced stabilization of pro-survival BCL-2 and p53 (mRNA). (D) ROS scavenging capacity of β-sitosterol blocked by IPI-504 (DCFH-DA assay). (E) Cell cycle analysis showing β-sitosterol alleviates UVA-induced G1 arrest, abrogated upon HSP90AA1 inhibition. (F) Western blot analysis confirming efficient knockdown of HSP90AA1 protein by specific siRNA (siHSP90AA1). (G) HSP90AA1 knockdown abolishes β-sitosterol’s stabilizing effect on p53 and BCL-2 mRNA levels under UVA stress. (H) HSP90AA1 knockdown blocks the ability of β-sitosterol to scavenge UVA-induced ROS. (I) ROS scavenging capacity of Tam (1 μmol/L). (J) Cell cycle analysis showing Tam alleviates UVA-induced G1 arrest. Data shown as mean ± SEM, n = 3, * p < 0.05, ** p < 0.01, *** p < 0.001.

Article Snippet: The cells were maintained at 37°C in an atmosphere containing 5% CO2. β-sitosterol (Tokyo Chemical Industry, Tokyo, Japan) was dissolved in the culture medium and used at a concentration of 25, 50 or 100 μg/mL for 24 h treatment.

Techniques: Expressing, DCFH-DA Assay, Cell Cycle Assay, Inhibition, Western Blot, Knockdown